Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors.

摘要: The standard reference for pathogenic and nonpathogenic amoebae is the human parasite Entamoeba histolytica; a direct correlation between virulence protease expression has been demonstrated this amoeba. Traditionally, proteases are considered factors, including those that produce cytopathic effects in host or have implicated manipulating immune response. Here, we expand scope to other amoebae, less-pathogenic species highly free-living amoebae. In paper, affect mucin, extracellular matrix, system components, diverse tissues cells included, based on studies amoebic cultures animal models. We also include used by degrade iron-containing proteins because iron scavenger capacity currently factor pathogens. addition, role adhesion encystation, which essential establishing transmitting infection, discussed. study of their specific inhibitors relevant search new therapeutic targets increase power drugs treat diseases caused these complex microorganisms.