Biochemistry of nonheme iron in man. I. Iron proteins and cellular iron metabolism.

摘要: Total plasma iron turnover in man is about 36 mg/day. Transferrin the transport protein of plasma, which can bind 2 atoms per molecule, and interacts with various cell types to provide them required for their metabolic proliferative processes. All tissues contain transferrin receptors on membrane surfaces, interact preferentially diferric transferrin. In erythroid cells as well certain laboratory lines, removal from apparently proceeds via receptor-mediated endocytosis process. its receptor are recycled surface, whereas remains cell. The mode uptake hepatocyte, main storage tissue, less certain. release by hepatocytes, reticuloendothelial cells, nonspecifically. ferritin, stores ferric state, though must be ferrous state enter exit ferritin molecule. Cellular cytosol also contains a small-molecular-weight pool, may protoporphyrin form heme, exported hepatocytes macrophages. converted into action ceruloplasmin.