Exploitation of hypoxia for radiation therapy: a lesson from phenothiazines.

摘要: Abstract In experimental radiation therapy of tumours, phenothiazines are known to sensitize hypoxic cancer cells while offering protection the normal surrounding tissue. It is hypothesized that differential radiosensitization tumour and radioprotection by related presence Fe 2+ 3+ ion concentration respectively. As a result changed biochemical environment such as pH, hypoxia accumulation ferritin, in especially cells, expected be higher (and further enhanced irradiation) than well-oxygenated cells. iron would predominantly form, which might increase protective effect phenothiazines. A many-fold has been shown us vivo well vitro systems combined ions. Our findings suggest condition can exploited for employing suitable metal-based chemomodulation.