Exposure to Mono-n-Butyl Phthalate in Women with Endometriosis and Its Association with the Biological Effects on Human Granulosa Cells.

摘要: To study the association between urinary phthalate metabolite levels, endometriosis, and their effects on human granulosa cells, we recruited patients who underwent laparoscopy to confirm endometriosis (n = 123) control 78). Liquid chromatography-tandem mass spectrometry was used measure following five metabolites: mono-n-butyl (MnBP), mono(2-ethylhexyl) phthalate, monobenzyl mono(2-ethyl-5-oxo-hexyl) mono(2-ethyl-5-hydroxyhexyl) phthalate. Urinary MnBP levels were higher in with than controls after multivariable logistic regression including number of deliveries, body index, use medicine as covariables. correlates other metabolites. Previous studies found that a detrimental condition for cells. In our study, observed whether affected treatment altered gene expression BIRC5, BUB1B, CDC20, cyclin B1, IL-1β, TNF-α, inhibin-B, StAR, P450ssc attenuated ratio mitochondrial membrane potential Moreover, decreased anti-Mullerian hormone. These findings suggest concentration is associated may affect health steroidogenesis