Urinary phthalate monoesters and endometriosis in infertile Japanese women.
作者： Hiroaki Itoh , Motoki Iwasaki , Tomoyuki Hanaoka , Hiroshi Sasaki , Tadao Tanaka
DOI: 10.1016/J.SCITOTENV.2009.09.012
关键词:
摘要: Phthalates may act as an estrogen and are a potential risk factor for estrogen-related diseases such endometriosis. We assessed the association between phthalate exposure endometriosis in 166 consecutive women who presented at university hospital consultation regarding infertility. The subjects were interviewed provided urine specimen prior to laparoscopic diagnosis of They then categorized by severity controls (stages 0-I) cases II-IV). Urinary concentrations metabolites monoethyl phthalate, mono-n-butyl monobenzyl mono(2-ethylhexyl) (MEHP), mono(2-ethyl-5-oxohexyl) mono(2-ethyl-5-hydroxyhexyl) measured 57 80 using high-performance liquid chromatography isotope-dilution tandem mass spectrometry. Adjusted odds ratios relation dichotomized individual (standardized creatinine) calculated. No significant any urinary creatinine-adjusted monoester was seen. ratio (95% confidence interval) higher MEHP 1.57 (0.74-3.30). monotonic trend seen concentration stage (p=0.23-0.90). Our results do not support hypothesis that associated with infertile Japanese women.
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