Omega-3 fatty acid-containing liposomes in cancer therapy.

摘要: omega-3 fatty acids are associated with reduced growth and incidence of certain cancers, in this report we demonstrate that a fish oil diet (rich acids) enhances the longevity mice bearing myeloid leukemia T27A. We have proposed acid docosahexaenoic (DHA, 22:6 delta 4,7,10,13,16,19) may induce structural changes tumor cell plasma membranes resulting vitro. Here, test whether liposomes containing DHA (18:0, PC) antitumor effects vivo, leading to enhanced tumor-bearing host. Male BALB/c (6-8 weeks old) were inoculated intraperitoneally T27A dose known cause 100% mortality syngeneic (BALB/c) less than 2 weeks. Small unilamellar vesicles (liposomes) prepared, composed phosphatidylcholine (PC) 18:0 sn-l position one following sn-2 position: 18:0, 18:1 omega 9 (oleic), 18:3 3 (alpha-linolenic), 20:4 6 (arachidonic), (docosahexaenoic). The injected into at various times: concurrently inoculum, select times during growth, when moribund. Mouse survival was then charted. DHA-containing lipid caused statistically significant increase compared PC. Lipid PC showed no benefit, not significantly different acid, PC, also effectively mouse survival. greatest benefit achieved if either liposome treatments spaced throughout period, or inoculum suspended preparation (without further treatments). Neither peroxidation nor prolonged inflammatory responses appeared be pertinent, leaving membrane as feasible mode action. With properties their own, acid-containing offer an important new avenue combination cancer therapies.