Peripheral benzodiazepine receptors in the brain of cirrhosis patients with manifest hepatic encephalopathy
作者： Peter Iversen , Dorthe Aagaard Hansen , Dirk Bender , Anders Rodell , Ole Lajord Munk
DOI: 10.1007/S00259-005-0052-8
关键词:
摘要: Purpose It has been suggested that ammonia-induced enhancement of peripheral benzodiazepine receptors (PBRs) in the brain is involved development hepatic encephalopathy (HE). This hypothesis based on animal experiments and studies post-mortem human brains using radiolabelled PK11195, a specific ligand for PBR, but to our knowledge not tested living patients. The aim present study was test this by measuring number cerebral PBRs regions cirrhotic patients with an acute episode clinically manifest HE healthy subjects dynamic 11C-PK11195 PET.
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forskningsdatabasen.dk参考文章(40)
Mark Rayport, Pierre Tournoux, J. Talairach, Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging Published in <b>1988</b> in Stuttgart by Thieme. ,(1988)
Thomas C. Gasser, In Vitro Studies Fortschritte der Urologie und Nephrologie. pp. 12- 12 ,(1992) , 10.1007/978-3-642-85422-4_3
G. Le Fur, M.L. Perrier, N. Vaucher, F. Imbault, A. Flamier, J. Benavides, A. Uzan, C. Renault, M.C. Dubroeucq, C. Guérémy, Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamide: I. In vitro studies Life Sciences. ,vol. 32, pp. 1839- 1847 ,(1983) , 10.1016/0024-3205(83)90062-0
Roger F. Butterworth, Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metabolic Brain Disease. ,vol. 17, pp. 221- 227 ,(2002) , 10.1023/A:1021989230535
M. E. Raichle, J. Markham, P. Herscovitch, W. R. W. Martin, M. A. Mintun, Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. The Journal of Nuclear Medicine. ,vol. 24, pp. 790- 798 ,(1983)
A J Cooper, F Plum, Biochemistry and physiology of brain ammonia. Physiological Reviews. ,vol. 67, pp. 440- 519 ,(1987) , 10.1152/PHYSREV.1987.67.2.440
V. Papadopoulos, H. Amri, N. Boujrad, C. Cascio, M. Culty, M. Garnier, M. Hardwick, H. Li, B. Vidic, A.S. Brown, J.L. Reversa, J.M. Bernassau, K. Drieu, Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids. ,vol. 62, pp. 21- 28 ,(1997) , 10.1016/S0039-128X(96)00154-7
Yossef Itzhak, Michael D Norenberg, Ammonia-induced upregulation of peripheral-type benzodiazepine receptors in cultured astrocytes labeled with [3H]PK 11195 Neuroscience Letters. ,vol. 177, pp. 35- 38 ,(1994) , 10.1016/0304-3940(94)90038-8
M. D. Norenberg, L. W. Lapham, F. A. Nichols, A. G. May, An Experimental Model for the Study of Hepatic Encephalopathy JAMA Neurology. ,vol. 31, pp. 106- 109 ,(1974) , 10.1001/ARCHNEUR.1974.00490380054006
Harold O. Conn, Milton M. Lieberthal, Harvey N. Mandell, The hepatic coma syndromes and lactulose Journal of Clinical Gastroenterology. ,vol. 2, pp. 216- ,(1980) , 10.1097/00004836-198006000-00023