GAPDH mediates nitrosylation of nuclear proteins
作者： Michael D. Kornberg , Nilkantha Sen , Makoto R. Hara , Krishna R. Juluri , Judy Van K. Nguyen
DOI: 10.1038/NCB2114
关键词:
摘要: S-nitrosylation of proteins by nitric oxide is a major mode of signalling in cells. S-nitrosylation can mediate the regulation of a range of proteins, including prominent nuclear proteins, such as HDAC2 (ref.) and PARP1 (ref.). The high reactivity of the nitric oxide group with protein thiols, but the selective nature of nitrosylation within the cell, implies the existence of targeting mechanisms. Specificity of nitric oxide signalling is often achieved by the binding of nitric oxide synthase (NOS) to target proteins, either directly or through scaffolding proteins …
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