Surface Modification of Nanoporous Alumina Surfaces with Poly(ethylene glycol)

摘要: Nanoporous alumina surfaces have a variety of applications in biosensors, biofiltration, and targeted drug delivery. However, the fabrication route to create these nanopores results surface defects crystal lattice. This inherent charge on porous causing biofouling, that is, nonspecific adsorption biomolecules. Poly(ethylene glycol) (PEG) is known form biocompatible nonfouling films silicon surfaces. its application very limited has not been well investigated. In this study, we covalently attached PEG nanoporous improve their properties. A PEG-silane coupling technique was used modify surface. Different concentrations for different immobilization times were various grafting densities. X-ray photoelectron spectroscopy (XPS) verify presence moieties High-resolution C1s spectra show with an increase concentration time, density also increases. Further, standard overlayer model calculate thickness formed using XPS intensities Al2p peaks. The by are less than 2.5 nm thick, suggesting such will clog pores which range 70-80 nm.