Comparative muscle transcriptome associated with carcass traits of Nellore cattle

摘要: Commercial cuts yield is an important trait for beef production, which affects the final value of products, but its direct determination a challenging procedure to be implemented in practice. The measurement ribeye area (REA) and backfat thickness (BFT) can used as indirect measures meat yield. REA BFT are traits studied cattle due their strong implication technological (carcass yield) nutritional characteristics like degree muscularity total body fat. Thus, aim this work was study Longissimus dorsi muscle transcriptome Nellore cattle, associated with BFT, find differentially expressed (DE) genes, metabolic pathways, biological processes that may regulate these traits. By comparing gene expression level between groups extreme genomic estimated breeding values (GEBV), 101 DE genes 18 (false discovery rate, FDR 10%) were identified. Functional enrichment analysis identified two KEGG MAPK (Mitogen-Activated Protein Kinase) signaling pathway endocytosis pathway, three processes, response endoplasmic reticulum stress, cellular protein modification process, macromolecule modification. responsible fundamental such growth, differentiation, hypertrophy. For found altered grouped into 8 clusters semantically similar terms. ACHE, SRD5A1, RSAD2 RSPO3. has been previously shown lipid droplet content biosynthesis. In study, we involved proliferation, turnover, hypertrophy, well adipogenesis biosynthesis related BFT. These results enlighten some molecular fat deposition, economically carcass production.