Survival time of HIV-infected patients with cryptococcal meningitis.

摘要: Objective: To study survival time and risk factors of mortality among HIV-infected patients who had cryptococcal meningitis. Design: Retrospective cohort study. Material Method: Patients’ medical records those HIV-infection with newly diagnosed cryptoccocal meningitis between January 2002 December 2004 were reviewed. Each patient was classified into one two groups, according to their anti-retroviral status (ART). Results: Five hundred forty nine enrolled in the present study: 281 (51.2%) ART+ group and 268 (48.8%) ART-group. The mean age 33.4 + 6.9 years old ART group 33.6 7.0 years There more male both groups: 207 males 74 females ART+ group, 195 73 Baseline CD4 cell count groups 20 (6-74) cells/ mL 24 (9-72) cells/ ml. About 30% experienced major opportunistic infection before cryptococcal meningitis. All treated by standard amphotericin B for a 2-week duration followed fluconazole an additional 8 weeks. no differences baseline characteristics between (p > 0.05). rates at 12, 24, 36 months 92.8%, 87.4%, 85.4% in 55.3%, 42.2%, 36.8% ART– group, respectively < 0.01). median survival ART- 15 months. From Cox regression model, hazard ratio “not received ART” 4.87 (95%CI = 2.48-9.44, p Conclusion: demonstrated substantial increasing HIV-infected patients initiated ART, even resource limited setting (no flucytosine, local combined antiretroviral drugs NVP based regimens). Keywords: HIV/AIDS, Cryptococcal meningitis, Survival time, Antiretroviral therapy, GPO-VIR