Resistance of Asian Cryptococcus neoformans Serotype A Is Confined to Few Microsatellite Genotypes

摘要: Background: Cryptococcus neoformans is a pathogenic yeast that causes cryptococcosis, life threatening disease. The prevalence of cryptococcosis in Asia has been rising after the onset AIDS epidemic and estimates indicate more than 120 cases per 1,000 HIV-infected individuals year. Almost all cryptococcal disease both immunocompromised immunocompetent patients are caused by C. var. grubii. Epidemiological studies on pan-Asia have not reported. present work genetic diversity fungus microsatellite typing susceptibility analysis approximately 500 isolates from seven Asian countries. Methodology/Principal Findings: Genetic was determined using with nine markers. revealed eight complexes (MCs) which showed different distributions among geographically defined populations. A correlation between MCs HIV-status observed. Microsatellite complex 2 mainly associated HIV-negative patients, whereas MC8 those HIV-positive patients. Most were susceptible to amphotericin B, itraconazole, voriconazole, posaconazole, isavuconazole, but 17 (3.4%) 10 (2%) found be resistant 5-flucytosine fluconazole, respectively. Importantly, five Indonesian (approximately 12.5% investigated 1% total studied isolates) antifungals. majority belonged MC17. Conclusions: findings distribution genotypes grubii various countries Asia, as well original source strains resistance 5-flucytosine.