The cardiorespiratory response to anoxia: normal development and the effect of nicotine

摘要: Maternal smoking increases the risk of sudden infant death syndrome (SIDS) 2-4-fold. The mechanism is unknown but may be related to hypoxia responses. Recovery from hypoxic apnea by young mammals depends on gasping and bradycardia. We asked whether prenatal nicotine exposure, reported reduce survival in 2 day old rat pups, acted impairing or Pregnant rats were infused throughout gestation 1 week postnatally with tartrate (NIC) 12 mg/kg per saline (CON). plasma was 134.4 +/- 42 ng/ml, significantly reducing pup body weight. Pups at 3-28 days exposed anoxia (97% N2/3% CO2) until ceased, while breathing heart rate recorded. NIC CON groups not different any age, baseline rate, respiratory time course for bradycardia, gasp onset, duration gasping, number gasps, although most these variables declined age. conclude that responses are affected high-dose nicotine.