Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells.

摘要: Inappropriate immune responses, thought to exacerbate or even initiate several types of central nervous system (CNS) neuropathology, could arise from failures by either the CNS system. The extent that inappropriate appearance antigen-presenting cell (APC) function contributes inflammation and pathology is still under debate. Therefore, we characterized response initiated when professional APCs (dendritic cells) presenting non-CNS antigens were injected into CNS. These dendritic cells expressed numerous T-cell chemokines, but only in presence antigen did leukocytes accumulate ventricles, meninges, subarachnoid spaces, injection site. Within parenchyma, migrated preferentially white matter tracts, yet a small percentage recruited entered then tracts. Although recruitment was specific thus mediated CD4 + T models used here, CD8 accumulated numbers equal greater than cells. Few activation markers (CD25 VLA-4), those primarily site, perivascular spaces not parenchyma. results indicate 1) modulates cellular composition states responding populations 2) myelin-restricted need be myelin-specific antigen.