Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele.

作者: Nunzio Pomara , Binbin Shao , Thomas Wisniewski , Pankaj D. Mehta

DOI: 10.1023/A:1020936222286

关键词:

摘要: This report examines plasma amyloid β proteins Aβ40 and Aβ42 apolipoprotein E (apoE) levels their relationships with age in non-demented older adults (N = 32) or without the apoE-e4 allele 94). Aβ did not differ between groups whereas e4 was associated a significant reduction apoE. In subjects allele, increasing Aβ40. Subjects showed positive correlation levels. There also apoE all subjects.

参考文章(22)
Eric Boerwinkle, G. Utermann, Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. American Journal of Human Genetics. ,vol. 42, pp. 104- 112 ,(1988)
A. Golabek, T. Wisniewski, E. M. Castaño, B. Frangione, T. Vogel, ACCELERATION OF ALZHEIMER'S FIBRIL FORMATION BY APOLIPOPROTEIN E IN VITRO American Journal of Pathology. ,vol. 145, pp. 1030- 1035 ,(1994)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
S Kataoka, M Paidi, B V Howard, Simplified isoelectric focusing/immunoblotting determination of apoprotein E phenotype. Clinical Chemistry. ,vol. 40, pp. 11- 13 ,(1994) , 10.1093/CLINCHEM/40.1.11
D.Larry Sparks, Stephen W. Scheff, Huaichen Liu, Teresa Landers, Fred Danner, Carolyn M. Coyne, John C. Hunsaker, Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: comparison to confirmed Alzheimer's disease patients Journal of the Neurological Sciences. ,vol. 138, pp. 97- 104 ,(1996) , 10.1016/0022-510X(96)00008-1
Cynthia L. Martel, Jasmina B. Mackic, Etsuro Matsubara, Samuel Governale, Calero Miguel, Wesley Miao, J. Gordon McComb, Blas Frangione, Jorge Ghiso, Berislav V. Zlokovic, Isoform‐Specific Effects of Apolipoproteins E2, E3, and E4 on Cerebral Capillary Sequestration and Blood‐Brain Barrier Transport of Circulating Alzheimer's Amyloid β Journal of Neurochemistry. ,vol. 69, pp. 1995- 2004 ,(2002) , 10.1046/J.1471-4159.1997.69051995.X
R. Benjamin, A. Leake, P.G. Ince, R.H. Perry, I.G. McKeith, J.A. Edwardson, C.M. Morris, Effects of Apolipoprotein E Genotype on Cortical Neuropathology in Senile Dementia of the Lewy Body and Alzheimer's Disease Neurodegeneration. ,vol. 4, pp. 443- 448 ,(1995) , 10.1006/NEUR.1995.0053
Terho Lehtim�ki, Tuula Pirttil�, PankajD. Mehta, HenrykM. Wisniewski, Harry Frey, Tapio Nikkari, Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease Human Genetics. ,vol. 95, pp. 39- 42 ,(1995) , 10.1007/BF00225071
Lawrence M. Maness, William A. Banks, Marcia B. Podlisny, Dennis J. Selkoe, Abba J. Kastin, Passage of human amyloid β-protein 1–40 across the murine blood-brain barrier Life Sciences. ,vol. 55, pp. 1643- 1650 ,(1994) , 10.1016/0024-3205(94)00331-9