A comparison of two fMRI methods for predicting verbal memory decline after left temporal lobectomy: Language lateralization versus hippocampal activation asymmetry

摘要: Summary Purpose:  Language lateralization measured by preoperative functional magnetic resonance imaging (fMRI) was shown recently to be predictive of verbal memory outcome in patients undergoing left anterior temporal lobe (L-ATL) resection. The aim this study determine whether language or the hippocampus is a better predictor setting. Methods:  Thirty L-ATL underwent fMRI, hippocampal fMRI using scene encoding task, and pre- postoperative neuropsychological testing. A group 37 right ATL (R-ATL) surgery included for comparison. Results:  Verbal decline occurred roughly half patients. Preoperative correlated with change. Hippocampal activation asymmetry strongly related side seizure focus Wada but unrelated outcome. Discussion:  elicited task not outcome. Risk likely material-specific networks, which are more closely than overall episodic processes.