摘要: Interleukin-5 (IL-5) stimulates proliferation and differentiation of B cells eosinophils. IL-5 receptor (IL-5R) comprises alpha (beta)c chains. specifically binds to IL-5Ralpha induces the recruitment IL-5Ralpha. JAK2 JAK1 tyrosine kinases are constitutively associated with hIL-5Ralpha (beta)c, respectively activated upon stimulation. phosphorylations cellular proteins including STAT5 activates Btk. X-linked immunodeficient mice have B-cell-specific defects due missense mutation btk gene. The cytoplasmic proline-rich regions both essential for signalling. appears play a critical role in hypereosinophilic syndromes atopic diseases. treatment animals anti-IL-5 mAb can decrease enhanced bronchial responsiveness induced by allergen sensitization. Clinical studies provide strong impetus investigating means modulating effects.
elsevier.com
researchgate.net 
sci-hub.se 参考文章(64)
Christopher J. Bagley, Joanna M. Woodcock, Frank C. Stomski, Angel F. Lopez, The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors Blood. ,vol. 89, pp. 1471- 1482 ,(1997) , 10.1182/BLOOD.V89.5.1471
N Yamaguchi, K Takatsu, S Mita, Y Hitoshi, R Matsumoto, A Tominaga, M Ando, S Araki, M Matsumoto, Interleukin-5 induces maturation but not class switching of surface IgA-positive B cells into IgA-secreting cells. Immunology. ,vol. 66, pp. 32- 38 ,(1989)
CJ Sanderson, Interleukin-5, Eosinophils, and Disease Blood. ,vol. 79, pp. 3101- 3109 ,(1992) , 10.1182/BLOOD.V79.12.3101.3101
A.L. Mui, H. Wakao, A.M. O'Farrell, N. Harada, A. Miyajima, Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. The EMBO Journal. ,vol. 14, pp. 1166- 1175 ,(1995) , 10.1002/J.1460-2075.1995.TB07100.X
Akira Matsumoto, Masaaki Masuhara, Kaoru Mitsui, Masahiro Yokouchi, Motoaki Ohtsubo, Hiroyuki Misawa, Atsushi Miyajima, Akihiko Yoshimura, CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood. ,vol. 89, pp. 3148- 3154 ,(1997) , 10.1182/BLOOD.V89.9.3148
S. Takaki, S. Mita, T. Kitamura, S. Yonehara, N. Yamaguchi, A. Tominaga, A. Miyajima, K. Takatsu, Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor. The EMBO Journal. ,vol. 10, pp. 2833- 2838 ,(1991) , 10.1002/J.1460-2075.1991.TB07832.X
Takaho A. Endo, Masaaki Masuhara, Masahiro Yokouchi, Ritsu Suzuki, Hiroshi Sakamoto, Kaoru Mitsui, Akira Matsumoto, Shyu Tanimura, Motoaki Ohtsubo, Hiroyuki Misawa, Tadaaki Miyazaki, Nogueira Leonor, Tadatsugu Taniguchi, Takashi Fujita, Yuzuru Kanakura, Seturo Komiya, Akihiko Yoshimura, A new protein containing an SH2 domain that inhibits JAK kinases Nature. ,vol. 387, pp. 921- 924 ,(1997) , 10.1038/43213
F D Finkelman, J J Mond, J Smith, M Schaefer, Lyb-5- B cells of CBA/N mice can be induced to synthesize DNA by culture with insolubilized but not soluble anti-Ig. Journal of Immunology. ,vol. 131, pp. 2107- 2109 ,(1983)
A. Yoshimura, M. Ichihara, I. Kinjyo, M. Moriyama, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, T. Hara, A. Miyajima, Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. The EMBO Journal. ,vol. 15, pp. 1055- 1063 ,(1996) , 10.1002/J.1460-2075.1996.TB00443.X
Alice K. Berning, Irwin Scher, Richard Asofsky, X-Linked B Lymphocyte Defect in CBA/N Mice IV. Cellular and Environmental Influences on the Thymus Dependent IgG anti-Sheep Red Blood Cell Response Journal of Immunology. ,vol. 123, pp. 477- 486 ,(1979)