At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo

摘要: Neural stem and progenitor cells express a variety of receptors that enable them to sense react signals emanating from physiological pathophysiological conditions in the brain as well elsewhere body. Many these were first described investigations immune system, particularly with respect hematopoietic cells. This emerging view neurobiology has two major implications. First, many phenomena known system may actually be generalizable organ systems, reflecting cells' progenitor-mediated regenerative potential. Second, interfaces exist between diverse systems; populations neuroectodermal origin interact play crucial role normal physiology, pathology, repair. An understanding origins neural progenitors' responses might lead development effective therapeutic strategies counterbalance acute chronic neurodegenerative processes. Such include modifying modulating potential subtle ways. For example, able detect pathology-associated used "interpreters" mediate drug other interventions. review focused on inflammation We propose resident astroglia blood-born both contribute an inflammatory signature is unique each kind neuronal degeneration or injury. These key coordinating cell response injury by exerting direct indirect environmentally mediated influence suggest progenitor-immunologic interface will provide valuable data related mechanisms which endogenous exogenous ultimately aiding design more applications biology. improvements include: (1) ascertaining proper timing for implanting relation administration anti-inflammatory agents; (2) identifying what types molecules administered during enhance mobilization differentiation while also inhibiting detrimental aspects reaction; (3) divining clues required change lesioned environment order invite homing reparative