Disulfide Formation Strategies in Peptide Synthesis

摘要: Disulfide bonds play an important role in both proteins and peptides. They cause conformational constraints increase the stability of such molecules. In nature, disulfide are very common animal plant peptide toxins. These disulfide-rich peptides typically bind selectively with high affinities to their targets. Disulfide-rich great importance as potential therapeutics. Robust, convenient, efficient methods needed order prepare facilitate drug discovery process. This microreview explores new cysteine protecting groups that replace obsolete groups, reduce racemization, or regioselective formation, formation strategies assist synthesis complex peptides, use selenocysteine direct formation.