Wavelength-selective photoactivatable protecting groups for thiols.
作者： Nico Kotzur , Benoît Briand , Michael Beyermann , Volker Hagen
DOI: 10.1021/JA907287N
关键词:
摘要: We developed and characterized efficient, remarkably water-soluble photolabile protecting groups for thiols based on 2-nitrobenzyl (coumarin-4-yl)methyl chromophores, among them two new ones. The allow, due to their different absorption maxima, wavelength-selective photocleavage of binary mixtures cysteine derivatives protected at the thiol function with various by irradiation light. concept was also functional S-protected residues in model peptide resact. Selective photolysis could be achieved peptides Ac0-Cys1(BCMACMOC),Cys8(7,8BCMCMOC)-resact Ac0-Cys1(C4MNB),Cys8(BCMACMOC)-resact light ≥402 nm or ≥436 wavelength, respectively, followed λ ≥ 325 nm.
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