Methods and Compositions for Localized Secretion of Anti-CTLA-4 Antibodies
作者： Michael Curran , James Allison
DOI:
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摘要: The present invention provides compositions and methods for effectuating the localized expression of anti-CTLA-4 antibody proximal to a target tissue in patient.
lens.org 参考文章(143)
Imre Kovesdi, Jason Gall, Thomas J. Wickham, Erik Falck-Pedersen, Ronald G. Crystal, Chimeric adenoviral coat protein and methods of using same ,(1998)
MH Finer, TJ Dull, L Qin, D Farson, MR Roberts, kat: A high-efficiency retroviral transduction system for primary human T lymphocytes Blood. ,vol. 83, pp. 43- 50 ,(1994) , 10.1182/BLOOD.V83.1.43.43
Elizabeth M. Jaffee, Ralph H. Hruban, Tim F. Greten, Mieke Schutte, Charles J. Yeo, Constance A. Griffin, Adam J. Adler, Laura A. Morsberger, Matthew Thomas, Jeanette Gossett, Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials. The cancer journal from Scientific American. ,vol. 4, pp. 194- 203 ,(1998)
Dummer R, GVAX (Cell Genesys). Current opinion in investigational drugs. ,vol. 2, pp. 844- ,(2001)
Hans E. Kaiser, Bela Bodey, Stuart E. Siegel, Failure of cancer vaccines : The significant limitations of this approach to immunotherapy Anticancer Research. ,vol. 20, pp. 2665- 2676 ,(2000)
Michael Yellin, Alan Korman, Tibor Keler, Tumor immunotherapy: preclinical and clinical activity of anti-CTLA4 antibodies. Current opinion in investigational drugs. ,vol. 6, pp. 582- 591 ,(2005)
Martin Denis Ryan, Claire Halpin, Expression of self-processing polyproteins in transgenic plants ,(1994)
David T. Curiel, Capsid-modified recombinant adenovirus and methods of use ,(2000)
M.D. Ryan, J. Drew, Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein. The EMBO Journal. ,vol. 13, pp. 928- 933 ,(1994) , 10.1002/J.1460-2075.1994.TB06337.X
Hyam I. Levitsky, Ivan Borrello, Universal GM-CSF expressing bystander human K562 cell line ,(2006)