Maternal gestational weight gain and objectively measured physical activity among offspring.

摘要: Objective Animal studies have suggested that maternal weight-related factors during pregnancy can program offspring physical activity in a sex-dependent manner. However, there is limited evidence humans. The purpose of this study was to investigate the association between gestational weight gain (GWG) and total (TPA) level determine whether these associations are moderated by sex or pre-pregnancy status. Method We studied 56 boys (mean age = 3.7 years, standard deviation (SD) 0.5) 57 girls 3.5±0.5 years) enrolled licensed childcare centers. TPA objectively measured using Actical® accelerometers. Information on body mass index (BMI), GWG, other were collected with health questionnaire. Associations as continuous variable categorically (inadequate, adequate, excessive), analysed linear mixed models take into account intraclass correlation clusters (childcare centers). Models adjusted for age, accelerometer weartime, socioeconomic status, BMI Results found significant interaction (P-value 0.009). In boys, greater GWG associated decreased (β -3.2 counts⋅1000−1/d, 95% confidence intervals (CI) -6.4–0.02, P-value 0.049). born mothers categorized overweight obese, followed an inverted U-shape curve squared -0.1 CI (-0.2 –-0.04), 0.005). contrast, U-shaped classified lean (pre-pregnancy BMI<25 kg/m2) 0.7 0.2–1.2, 0.011). higher among women inadequate compared adequate 0.0137), whereas no differences 0.107). Conclusion Maternal be important biological marker TPA. These findings support early developmental programming influence