Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease
作者： Yasuhisa Kurogi
DOI: 10.1002/MED.10028
关键词:
摘要: Mesangial cells (MC) serve a number of functions in the renal glomerular capillary including structural support tuft, modulation hemodynamics, and phagocytic function allowing removal macromolecules immune complexes. The proliferation MC is prominent feature disease IgA nephropathy, membranoproliferative glomerulonephritis, lupus nephritis, diabetic nephropathy. In experimental animal models frequently precedes linked to increase extracellular matrix mesangium glomerulosclerosis. Reduction by treatment with heparin, low-protein diet, or antibodies platelet-derived growth factor (PDGF), have been shown reduce expansion glomerulosclerotic changes. Therefore, inhibitors may offer therapeutic opportunities for proliferative disease. It also known that inhibited many kinds pharmacological drugs, example, angiotensin converting enzyme (ACE) inhibitors, leukotriene D(4) (LTD(4)) antagonists, PDGF metalloproteinases (MMP) 3-hydroxy-3 methyl glutaryl-coenzymeA (HMG-CoA) cyclin-dependent kinases (CDK) others. This review summarizes recently reported their properties on basis chemical structures.
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