SMAD2 and the relationship of colorectal cancer to inflammatory bowel disease.

摘要: Abstract Inflammatory bowel diseases (IBDs) affecting the colon [Crohn's disease (CD) and ulcerative colitis (UC)] are associated with an increased risk of colorectal cancer (CRC). Our previous work using oligonucleotide array data indicated that SMAD2 was significantly underexpressed in UC dysplastic tissue compared to benign UC. The aim this current study determine whether single nucleotide polymorphisms (SNPs) within gene IBD dysplasia/cancer. We performed SNP haplotype-based case-control association study. Leukocyte DNA obtained from 489 unrelated Caucasians (158 UC, 175 CD, 71 CRC, 85 controls). Eleven SNPs were genotyped. All 11 Hardy-Weinberg equilibrium control population. Strong linkage disequilibrium observed among nearly all SNPs. There no significant associations between allele or haplotype frequencies. Power calculations good power for single-marker analysis (>0.8) reasonably against effects 0.1-0.15 analysis. not development This incongruity our microarray findings genotype may be attributed mechanisms such as alternative splicing pre-mRNA and/or cross talk other cellular pathways.