Novel medications for asthma: a look at the future

作者: Bruce K Rubin , James B Fink

DOI: 10.1517/13543784.16.6.889

关键词:

摘要: The principal components of the asthmatic response are airways hyper-responsiveness, persistent inflammation and mucus hypersecretion. Although these inter-related, any can predominate at different times for patients each requires a approach to therapy. As result epithelial damage, there be abnormal repair mechanisms leading fixed airflow obstruction that has been termed ‘airways remodeling’. number highly effective therapeutic agents used treat asthma today, novel therapies being designed more specifically safely target better meet needs with asthma.

参考文章(63)
Graeme P Currie, Indacaterol Novartis/skyePharma. Current opinion in investigational drugs. ,vol. 7, pp. 457- ,(2006)
Chris J. Corrigan, Asthma refractory to glucocorticoids: the role of newer immunosuppressants. American journal of respiratory medicine : drugs, devices, and other interventions. ,vol. 1, pp. 47- 54 ,(2002) , 10.1007/BF03257162
GG Alvarez, M Schulzer, D Jung, JM FitzGerald, A systematic review of risk factors associated with near-fatal and fatal asthma. Canadian Respiratory Journal. ,vol. 12, pp. 265- 270 ,(2005) , 10.1155/2005/837645
Anne McKay, Bernard P. Leung, Iain B. McInnes, Neil C. Thomson, Foo Y. Liew, A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma Journal of Immunology. ,vol. 172, pp. 2903- 2908 ,(2004) , 10.4049/JIMMUNOL.172.5.2903
Chad K. Oh, Mast Cell Mediators in Airway Remodeling Chemical immunology and allergy. ,vol. 87, pp. 85- 100 ,(2005) , 10.1159/000087573
Robert Newton, Neil Holden, Inhibitors of p38 Mitogen-Activated Protein Kinase BioDrugs. ,vol. 17, pp. 113- 129 ,(2003) , 10.2165/00063030-200317020-00004
Chet L Leach, The CFC to HFA transition and its impact on pulmonary drug development. Respiratory Care. ,vol. 50, pp. 1201- 1208 ,(2005)
Michael Adamzik, Harald Groeben, Ramin Farahani, Nils Lehmann, Juergen Peters, Intravenous lidocaine after tracheal intubation mitigates bronchoconstriction in patients with asthma. Anesthesia & Analgesia. ,vol. 104, pp. 168- 172 ,(2007) , 10.1213/01.ANE.0000247884.94119.D5
Maria G Belvisi, David J Hele, Soft steroids: a new approach to the treatment of inflammatory airways diseases. Pulmonary Pharmacology & Therapeutics. ,vol. 16, pp. 321- 325 ,(2003) , 10.1016/S1094-5539(03)00105-6
Kian Fan Chung, Phosphodiesterase inhibitors in airways disease European Journal of Pharmacology. ,vol. 533, pp. 110- 117 ,(2006) , 10.1016/J.EJPHAR.2005.12.059