A nano-delivery system for bioactive ingredients using supercritical carbon dioxide and its release behaviors.
作者： Wenbei Situ , Xianliang Song , Shucan Luo , Yan Liang
DOI: 10.1016/J.FOODCHEM.2017.01.053
关键词:
摘要: For the purpose of ensuring bioavailability bioactive ingredients, a nano-delivery system with low toxicity was developed using supercritical carbon dioxide (SC-CO2). Compared to thin-film hydration (TFH), obtaining nano-scale liposomes is easier SC-CO2. The characteristic these also demonstrated by analysis particle size and morphology. An in vitro release study showed that produced SC-CO2 were resistant pH simulated gastric conditions. In intestinal environment, enteric solubility enhanced, which are important properties for controlled releasing ingredient. Furthermore, SC-CO2-produced had higher storage stability than those TFH. Analysis organic solvent residue gas chromatography–mass spectrometry (GC–MS) indicated lower A chemical free has been revealed ingredients.
sci-hub.se 参考文章(29)
Lisha Zhao, Feral Temelli, Jonathan M. Curtis, Lingyun Chen, Preparation of liposomes using supercritical carbon dioxide technology: Effects of phospholipids and sterols Food Research International. ,vol. 77, pp. 63- 72 ,(2015) , 10.1016/J.FOODRES.2015.07.006
Roberta Campardelli, Islane Espirito Santo, Elaine Cabral Albuquerque, Silvio Vieira de Melo, Giovanna Della Porta, Ernesto Reverchon, Efficient encapsulation of proteins in submicro liposomes using a supercritical fluid assisted continuous process Journal of Supercritical Fluids. ,vol. 107, pp. 163- 169 ,(2016) , 10.1016/J.SUPFLU.2015.09.007
Mary Ann Augustin, Yacine Hemar, Nano- and micro-structured assemblies for encapsulation of food ingredients Chemical Society Reviews. ,vol. 38, pp. 902- 912 ,(2009) , 10.1039/B801739P
Stefan Palzer, Food structures for nutrition, health and wellness. Trends in Food Science and Technology. ,vol. 20, pp. 194- 200 ,(2009) , 10.1016/J.TIFS.2009.02.005
Huayin Pu, Ling Chen, Xiaoxi Li, Fengwei Xie, Long Yu, Lin Li, An oral colon-targeting controlled release system based on resistant starch acetate: synthetization, characterization, and preparation of film-coating pellets. Journal of Agricultural and Food Chemistry. ,vol. 59, pp. 5738- 5745 ,(2011) , 10.1021/JF2005468
David Julian McClements, Eric Andrew Decker, Yeonhwa Park, Jochen Weiss, Structural design principles for delivery of bioactive components in nutraceuticals and functional foods. Critical Reviews in Food Science and Nutrition. ,vol. 49, pp. 577- 606 ,(2009) , 10.1080/10408390902841529
Seong Kyun Chung, Gye Hwa Shin, Min Kyo Jung, In Cheon Hwang, Hyun Jin Park, Factors influencing the physicochemical characteristics of cationic polymer-coated liposomes prepared by high-pressure homogenization Colloids and Surfaces A: Physicochemical and Engineering Aspects. ,vol. 454, pp. 8- 15 ,(2014) , 10.1016/J.COLSURFA.2014.03.095
Noah Ray Johnson, Trisha Ambe, Yadong Wang, Lysine-based polycation:heparin coacervate for controlled protein delivery Acta Biomaterialia. ,vol. 10, pp. 40- 46 ,(2014) , 10.1016/J.ACTBIO.2013.09.012
Esther de Paz, Ángel Martín, Antonio Estrella, Soraya Rodríguez-Rojo, Ana A. Matias, Catarina M.M. Duarte, María José Cocero, Formulation of β-carotene by precipitation from pressurized ethyl acetate-on-water emulsions for application as natural colorant Food Hydrocolloids. ,vol. 26, pp. 17- 27 ,(2012) , 10.1016/J.FOODHYD.2011.02.031
Chih-Chieh Chen, Tung-Hu Tsai, Zih-Rou Huang, Jia-You Fang, Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 74, pp. 474- 482 ,(2010) , 10.1016/J.EJPB.2009.12.008