Glycoconjugates and Neuroimmunological Diseases
作者： Hugh J. Willison
DOI: 10.1007/978-1-4939-1154-7_25
关键词:
摘要: A wide range of neuroimmunological diseases affect the central and peripheral nervous systems. These disorders are caused by autoimmune attack directed against structurally functionally diverse system antigens. One such category comprises (PNS) diseases, termed neuropathies, in which target antigens for autoantibody-directed nerve injury glycan structures borne glycoproteins glycolipids, particularly gangliosides that concentrated nerve. The archetypal PNS disorder is acute paralytic disease, Guillain–Barre syndrome (GBS) autoantibodies glycolipids arise context infections precede clinical onset, notably Campylobacter jejuni enteritis. In addition, several chronic neuropathies associated with IgM antibodies glycans including sulphated glucuronic acid epitopes present on myelin-associated glycoprotein glucuronyl paragloboside, a disialylated GD1b GD3, GM1 ganglioside. This chapter describes immunological, pathological features these our broader knowledge glycobiology underpinning this field.
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