Gout as a risk factor for osteoporosis: epidemiologic evidence from a population-based longitudinal study involving 108,060 individuals

摘要: Is gout a risk factor for future osteoporosis? This large population-based study comprising two matched groups of individuals with and without demonstrates that patients have 20% increase in the developing osteoporosis through an 8-year follow-up. To examine if is associated increased osteoporosis. We conducted nationwide retrospective matched-cohort study. Two cohorts (n = 36,458 71,602 gout) assembled recruited from Longitudinal Health Insurance Dataset containing 1 million subjects. Exclusion criteria were missing data, age < 20 years, short follow-up period, pre-existing Both followed up until incident osteoporosis, death, or end Person-year data incidence rates evaluated. A multivariable Cox model was used to derive adjusted hazard ratio (aHR) after controlling socioeconomic proxy, geographical difference, glucocorticoid allopurinol exposure, various prespecified medical conditions, comorbidities. Men comprised 72.8% cohorts. With 183,729 359,900 person-years non-gout cohorts, 517 811 incidents occurred, respectively, excluding first 3 years The cumulative statistically higher cohort than cohort, at 3.3 versus 2.1% (P = 0.0036, log-rank). Our showed 1.2-fold aHR 1.2 (95% confidence interval, 1.06–1.35). epidemiologic supports hypothesis compared gout; those modest future.