Biochemical and molecular basis of microbial synthesis of polyhydroxyalkanoates in microorganisms.

摘要: Intensive research on the physiology, biochemistry, and molecular genetics of metabolism polyhydroxyalkanoates (PHA) during last 15 years has revealed a dramatic increase our knowledge biosynthesis these polyesters in bacteria. This mainly very basic several new, hitherto not described enzymes pathways. In addition, many genes encoding pathways particular key enzyme PHA biosynthesis, synthase, were cloned characterized at level. was utilized to establish prokaryotic eukaryotic organisms, which unable synthesize PHAs, apply methodology metabolic engineering, thus opening new perspectives for production various PHAs by fermentation biotechnology or agriculture economically feasible processes. contribution summarizes properties synthases gives an overview other that have been are available. It also current regulation gene level