Effects of TNF, IL-1, and the combination of both cytokines on cholesterol metabolism in Syrian hamsters.

摘要: Infection and inflammation are associated with alterations in lipid metabolism that may be mediated by cytokines such as TNF IL-1. This study determined the effects of IL-1 on certain aspects cholesterol metabolism. or administration to Syrian hamsters increased serum levels 17 21%, respectively, decreased HDL 20 15%, respectively. + 58% 58%. hepatic HMG CoA reductase mRNA 3.5- 3-fold, 7-fold. LDL receptor 2-fold while a combination had minimal effects. did not affect apo E A-I both 50%. Our results demonstrate similarly parameters studied. Furthermore, was, most cases, more effective than either cytokine alone, reproduced many LPS.