Scaffold Library for Tissue Engineering: A Geometric Evaluation

摘要: Tissue engineering scaffold is a biological substitute that aims to restore, maintain, or improve tissue functions. Currently available manufacturing technology, is, additive essentially applied fabricate the according predefined computer aided design (CAD) model. To develop CAD libraries, polyhedrons could be used in libraries development. In this present study, one hundred and nineteen polyhedron models were evaluated established criteria. The proposed criteria included considerations on geometry, feasibility, mechanical strength of these polyhedrons. finite element (FE) method employed as tools evaluation. result evaluation revealed close-cellular truncated octahedron, rhombicuboctahedron, rhombitruncated cuboctahedron. addition, suitable for using open-cellular hexahedron, cuboctahedron, However, not all pore size beam thickness ratios (PO:BT) good making scaffold. PO:BT ratio each library, generating enclosed inside scaffold, was excluded avoid impossibility material removal after fabrication. presented constant porosity which irrespective different sizes. relationship between displayed form Logistic Power function. possibility merging two types produce composite structure geometrically terms intersection index mechanically by means FE analysis observe stress level. couples presenting low high level excluded. Good producing reinforced hexahedron-truncated hexahedron cuboctahedron-rhombitruncated