Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study.

摘要: Abstract Hypothyroidism causes an imbalance in antioxidant and pro-oxidants criteria the brain enhances concentration of reactive oxygen species (ROS), neuronal damage has been observed following excessive ROS. The main purpose this study was to examine preventive effect vitamin C on hypothyroidism associated hippocampus neonatal juvenile rats. Pregnant rats after delivery their pups were randomly divided into four groups treated with (1) normal drinking water as a control group, (2) Propylthiouracil (PTU) 0.005% added water, (3-, 4) PTU + Vit C 10 mg/ kg 100 mg/ kg water. Treatment carried out during rat’s lactation period until postnatal day (PND) 60. To assess histological stereological changes that occur study, brains 5 male extracted. number dark neurons apoptotic cells hippocampal sub-regions PTU group significantly greater than group’s sub-regions. In addition, induced reduction volume increased numerical density total amount neurons. only dose 100 mg/kg reduced (P  current suggested administration possibility prevent caused by