CRH-BP: the regulation and function of a phylogenetically conserved binding protein

摘要: Corticotropin Releasing Hormone-Binding Protein (CRH-BP), a 37 kDa secreted glycoprotein, binds both CRH and urocortin with high affinity is structurally unrelated to the receptors. CRH-BP orthologues have been identified in multiple invertebrate vertebrate species. It strongly conserved throughout evolution, suggesting maintenance of structural conformation necessary for biological activity. an important modulator activity; it inhibits CRH-induced ACTH secretion from pituitary corticotropes may exert similar actions at central sites release. While function thought be primarily inhibitory, recent studies indicate that novel functional roles exist brain pituitary. Regulation expression by stress metabolic factors are consistent vivo models altered expression. Positive regulation reproductive hormones suggests additional interactions between axes exist. research has focused on evolutionary conservation, expanded expression, CRH-BP, more complete understanding peripheral functions its mechanisms action will help elucidate potential role etiology or treatment disorders dysregulation.