Radiologic abnormalities and autonomic neuropathology in the digestive tract of the ketonuric diabetic Chinese hamster.

作者: A. R. Diani , D. M. Grogan , M. E. Yates , D. L. Risinger , G. C. Gerritsen

DOI: 10.1007/BF01222975

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摘要: Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation the stomach, small and large intestine. Hypomotility was manifested by flocculation barium in bowel. Impaired transit time further characterized prolonged emptying stomach (mean 570 min diabetics; 200 controls) delayed stool formation 230 100 passage 457 210 controls). Ultrastructural analysis Auerbach's myenteric plexuses intestine indicated acute degeneration certain distal, unmyelinated axons. Swelling, deposition glycogen, aggregation neurofilaments dense accumulation lamellar bodies were observed. The severity frequency flocculation, glycogen deposition, inclusion axons directly related to duration ketonuria. data strongly suggest that autonomic neuropathology Auerbach may be a critical factor underlying gastrointestinal dysfunction hamster.

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