Gastrointestinal endocrine cells in an animal model for human type 2 diabetes.

摘要: Endocrine cells were investigated in various parts of the gastrointestinal tract an animal model for human type 2 diabetes, namely homozygous obese mouse. As controls, age- and sex-matched lean mice used. The different endocrine cell types stained by using immunocytochemistry quantified computerized image analysis. numbers PYY- enteroglucagon-immunoreactive (IR) decreased colon diabetic vis-a-vis controls. Serotonin-IR significantly duodenum colon. Furthermore, colonic serotonin had a high secretory index (CSI), but unchanged nuclear area, indicating impaired cellular release this amine. There was no statistical difference between controls regarding CSI antral gastrin/CCK-, somatostatin- serotonin-; duodenal secretin-, gastric inhibitory peptide (GIP)-, CCK/gastrin-, somatostatin-IR cells; nor there any with exception GIP-IR cells. It is concluded that abnormalities gut observed present study might explain dysmotility reported models diabetes. They may also be importance dysfunction occurring diabetes patients.