Notch3 pathway alterations in ovarian cancer
作者： Anil K. Sood , Wei Hu , Tao Liu , Cristina Ivan , Yunjie Sun
DOI: 10.1158/0008-5472.CAN-13-2066
关键词:
摘要: Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical biological mechanisms are not well understood. Here, we found that alterations prevalent significantly related to poor outcome patients with cancer. Particularly, Notch3 alterations, including amplification upregulation, were highly associated patient survival. Targeting inhibited OvCa induced apoptosis. Importantly, DNM-mediated endocytosis was required for selectively activating Jagged-1-mediated signaling. Cleaved expression critical determinant response Notch-targeted therapy. Collectively, these data identify previously unknown underlying signaling new, biomarker-driven approaches
aacrjournals.org
uq.edu.au参考文章(21)
Shinya Yamamoto, Wu-Lin Charng, Hugo J. Bellen, Endocytosis and Intracellular Trafficking of Notch and Its Ligands Current Topics in Developmental Biology. ,vol. 92, pp. 165- 200 ,(2010) , 10.1016/S0070-2153(10)92005-X
Henry E. Pelish, Tom Kirchhausen, Eric Macia, Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods in Enzymology. ,vol. 438, pp. 77- 93 ,(2008) , 10.1016/S0076-6879(07)38006-3
Xu Chen, Alexander Stoeck, Soo Jung Lee, Ie-Ming Shih, Michael M. Wang, Tian-Li Wang, Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer Oncotarget. ,vol. 1, pp. 210- 218 ,(2010) , 10.18632/ONCOTARGET.127
Robert Gentleman, Vincent J Carey, Wolfgang Huber, Rafael A Irizarry, Sandrine Dudoit, Bioinformatics and Computational Biology Solutions Using R and Bioconductor ,(2006)
G. K. Smyth, limma: Linear Models for Microarray Data Springer, New York, NY. pp. 397- 420 ,(2005) , 10.1007/0-387-29362-0_23
Spyros Artavanis-Tsakonas, Marc A.T. Muskavitch, Notch: The Past, the Present, and the Future Current Topics in Developmental Biology. ,vol. 92, pp. 1- 29 ,(2010) , 10.1016/S0070-2153(10)92001-2
D Bellavia, S Checquolo, A F Campese, M P Felli, A Gulino, I Screpanti, Notch3: from subtle structural differences to functional diversity. Oncogene. ,vol. 27, pp. 5092- 5098 ,(2008) , 10.1038/ONC.2008.230
Zhiwei Wang, Yiwei Li, Aamir Ahmad, Asfar S. Azmi, Sanjeev Banerjee, Dejuan Kong, Fazlul H. Sarkar, Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochimica et Biophysica Acta. ,vol. 1806, pp. 258- 267 ,(2010) , 10.1016/J.BBCAN.2010.06.001
Antonio F. Saad, Wei Hu, Anil K. Sood, Microenvironment and Pathogenesis of Epithelial Ovarian Cancer Hormones and Cancer. ,vol. 1, pp. 277- 290 ,(2010) , 10.1007/S12672-010-0054-2
Gladys W. Wong, Gisele C. Knowles, Tak W. Mak, Adolfo A. Ferrando, Juan Carlos Zúñiga-Pflücker, HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood. ,vol. 120, pp. 1439- 1448 ,(2012) , 10.1182/BLOOD-2011-12-395319