Notch pathway promotes ovarian cancer growth and migration via CXCR4/SDF1α chemokine system

作者: R. Chiaramonte , M. Colombo , G. Bulfamante , M. Falleni , D. Tosi

DOI: 10.1016/J.BIOCEL.2015.07.015

关键词:

摘要: Ovarian cancer is the most deadly gynecological malignancy. Understanding the molecular pathogenesis of ovarian cancer is critical to provide new targeted therapeutic strategies. …

参考文章(40)
Michela Colombo, Katja Thümmler, Leonardo Mirandola, Silvia Garavelli, Katia Todoerti, Luana Apicella, Elisa Lazzari, Marialuigia Lancellotti, Natalia Platonova, Moeed Akbar, Maurizio Chiriva-Internati, Richard Soutar, Antonino Neri, Carl S. Goodyear, Raffaella Chiaramonte, Notch signaling drives multiple myeloma induced osteoclastogenesis Oncotarget. ,vol. 5, pp. 10393- 10406 ,(2014) , 10.18632/ONCOTARGET.2084
Xiaoyan Shen, Shaohai Wang, Hongbo Wang, Minglin Liang, Lan Xiao, Zehua Wang, The role of SDF-1/CXCR4 axis in ovarian cancer metastasis Journal of Huazhong University of Science and Technology [Medical Sciences]. ,vol. 29, pp. 363- 367 ,(2009) , 10.1007/S11596-009-0320-0
Jin Hyun Kang, Da Hye Lee, Jong Soo Lee, Hai Joong Kim, Jin Woo Shin, Young Han Lee, Young Seek Lee, Choon-Sik Park, Il Yup Chung, Eosinophilic differentiation is promoted by blockage of Notch signaling with a gamma‐secretase inhibitor European Journal of Immunology. ,vol. 35, pp. 2982- 2990 ,(2005) , 10.1002/EJI.200526242
Michael J. Kluk, Todd Ashworth, Hongfang Wang, Birgit Knoechel, Emily F. Mason, Elizabeth A. Morgan, David Dorfman, Geraldine Pinkus, Oliver Weigert, Jason L. Hornick, Lucian R. Chirieac, Michelle Hirsch, David J. Oh, Andrew P. South, Irene M. Leigh, Celine Pourreyron, Andrew J. Cassidy, Daniel J. DeAngelo, David M. Weinstock, Ian E. Krop, Deborah Dillon, Jane E. Brock, Alexander J. F. Lazar, Myron Peto, Raymond J. Cho, Alexander Stoeck, Brian B. Haines, Sriram Sathayanrayanan, Scott Rodig, Jon C. Aster, Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry PLoS ONE. ,vol. 8, pp. e67306- ,(2013) , 10.1371/JOURNAL.PONE.0067306
Joon T. Park, Mei Li, Kentaro Nakayama, Tsui-Lien Mao, Ben Davidson, Zhen Zhang, Robert J. Kurman, Charles G. Eberhart, Ie-Ming Shih, Tian-Li Wang, Notch3 Gene Amplification in Ovarian Cancer Cancer Research. ,vol. 66, pp. 6312- 6318 ,(2006) , 10.1158/0008-5472.CAN-05-3610
Cassin Kimmel Williams, Marta Segarra, Maria De La Luz Sierra, Richard C.A. Sainson, Giovanna Tosato, Adrian L. Harris, Regulation of CXCR4 by the Notch Ligand Delta-like 4 in Endothelial Cells Cancer Research. ,vol. 68, pp. 1889- 1895 ,(2008) , 10.1158/0008-5472.CAN-07-2181
Gulperi Oktem, Muzaffer Sanci, Ayhan Bilir, Yusuf Yildirim, Sibel D. Kececi, Sule Ayla, Sevinc Inan, Cancer stem cell and embryonic development-associated molecules contribute to prognostic significance in ovarian cancer. International Journal of Gynecological Cancer. ,vol. 22, pp. 23- 29 ,(2012) , 10.1097/IGC.0B013E31823228B2
Stephen L. Rose, Muthusamy Kunnimalaiyaan, Jessica Drenzek, Nicole Seiler, Notch 1 signaling is active in ovarian cancer Gynecologic Oncology. ,vol. 117, pp. 130- 133 ,(2010) , 10.1016/J.YGYNO.2009.12.003
Raphael Kopan, Ma. Xenia G. Ilagan, The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism Cell. ,vol. 137, pp. 216- 233 ,(2009) , 10.1016/J.CELL.2009.03.045
Hiroaki Kajiyama, Kiyosumi Shibata, Mikio Terauchi, Kazuhiko Ino, Akihiro Nawa, Fumitaka Kikkawa, Involvement of SDF-1α/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma International Journal of Cancer. ,vol. 122, pp. 91- 99 ,(2008) , 10.1002/IJC.23083