Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1)

摘要: MRP1 (ABCC1) is a peculiar member of the ABC transporter superfamily for several aspects. This protein has an unusually broad substrate specificity and capable transporting not only wide variety neutral hydrophobic compounds, like MDR1/P-glycoprotein, but also facilitating extrusion numerous glutathione, glucuronate, sulfate conjugates. The transport mechanism complex; composite substrate-binding site permits both cooperativity competition between various substrates. versatility ubiquitous tissue distribution make this suitable contributing to physiological functions, including defense against xenobiotics endogenous toxic metabolites, leukotriene-mediated inflammatory responses, as well protection from effect oxidative stress. In paper, we give overview considerable amount knowledge which accumulated since discovery in 1992. We place special emphasis on structural features essential function, our recent understanding mechanism, assignments transporter.