Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.
作者： TatsuyaT. Abe , TeruakiT. Mori , YukihiroY. Wakabayashi , MasayukiM. Nakagawa , SusanS.P.C. Cole
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摘要: Two different ATP-binding membrane glycoproteins, the 170 kDa P-glycoprotein (P-gp) and 190 multidrug resistance protein (MRP), are involved in acquisition of phenotypes cancer cells. Overexpression P-gp is often observed various human tumors when treated with anticancer agents. In this study, we asked whether MRP was overexpressed gliomas after chemotherapy. We investigated expression before chemotherapy tumor samples from patients glioma. 16 (70%) 23 untreated patients, proportion MRP-positive cells whole cell population ranged 3 to 32% patients. P-gp-positive were 4 (18%) proportional rates 23%. The rate or glioma increased compared that all examined. could observe no statistically significant correlation between grade. These results suggest as well may be acquired intrinsic drug
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