Central orexin inhibits reflex swallowing elicited by the superior laryngeal nerve via caudal brainstem in the rat.
作者： Motoi Kobashi , Satoshi Mizutani , Masako Fujita , Yoshihiro Mitoh , Yuichi Shimatani
DOI: 10.1016/J.PHYSBEH.2014.03.009
关键词:
摘要: We examined the effects of orexins on reflex swallowing using anesthetized rats. Orexins were administered into fourth ventricle. Swallowing was induced by repeated electrical stimulation central cut end superior laryngeal nerve (SLN) and identified electromyogram lead penetrated mylohyoid muscle through bipolar electrodes. The frequency during SLN decreased after administration orexin-A in a dose-dependent manner. latency first tended to be extended orexin-A. orexin-B did not affect frequency. Pre-administration SB334867, an orexin-1 receptor antagonist, attenuated degree inhibition To identify effective site orexin-A, effect microinjection dorsal vagal complex (DVC) evaluated. Orexin-A injected one lateral DVC, intermediate or medial DVC. Microinjection DVC but other two sites Pre-injection SB334867 disrupted inhibitory response ventricular lesion commissural part NTS, ablation AP, abolished These results suggest that inhibits via receptors situated NTS and/or its vicinity.
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