On the significance of regional dopamine metabolism in the rat brain for the classification of centrally acting drugs

摘要: 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic (HVA) were measured in the corpus striatum, nucleus accumbens tuberculum olfactorium of rat brain, 4 antidepressants, anesthetics, dipropylacetate, ethosuximide metoclopramide induced a rise DOPAC HVA levels 3 brain regions. No change was observed after carbamazepine, diazepam or propranolol treatment. Combined treatment with maximally effective dose haloperidol morphine, oxotremorine probenecid produced an additional levels, while no seen chloral hydrate, chlorimipramine, ether, halothane, sulpiride. The potency drugs to increase DA metabolism striatum relative mesolimbic structures estimated. Atypical neuroleptics such as sulpiride could be differentiated this respect from classical chlorpromazine, fluphenazine thioridazine, by their ability produce relatively large metabolite heterogeneous group 14 non-neuroleptics however regional changes which very similar those atypical neuroleptics. regions, contrast striatal tissue, seems respond more than typical