Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain
作者： Ben H.C. Westerink , Jakob Korf
DOI: 10.1016/0014-2999(75)90134-X
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摘要: Abstract Homovanillic acid (HVA) was measured in the corpus striatum and limbic structures nucleus accumbens olfactory tubercle of rat, under normal conditions after different drug treatments. Clozapine, thioridazine, morphine physostigmine induced a similar percentage HVA increase three brain studied. Haloperidol pimozide higher when compared with tubercle. Oxotremorine highest levels accumbens. Probenecid significantly accumulation structures, especially The rise seen haloperidol suppressed by pretreatment p-chlorophenylalanine or amino-oxyacetic all After atropine trihexylphenidyl treatment slightly only. Our results suggest that not only but also various types drugs, dopamine metabolism as reflected levels, is closely related rat structures.
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