Response of Heme Oxygenase and Telomerase Enzymes to Oxidative Stress in Human Hepatoma Cell Line (HepG2)

摘要: Telomerase, a specialized reverse transcriptase enzyme, maintains the telomere length by adding new telomeric repeats onto chromosome ends using part of constituent RNA molecule as template for synthesizing repeat.1 The enzymatic core human telomerase minimally consists (hTR) and catalytic subunit homology protein (hTERT).2,3 Other components such hTEP14 are not required action in vitro, but telomerase-associated proteins may serve key roles allowing to act at complex vivo.5 Telomerase is expressed widely during embryogenesis but, adults, expression limited primary germ cells, early progenitor/stem stimulated cycling lymphocytes.6 activity has been reported many types malignant tumors, including neuroblastomas,7 lung carcinomas,8 gastric colon carcinomas,9 bladder carcinoma10 brain tumors.11 Ogami et al.12 detected high level most hepatocellular carcinoma tissues; however, very weak was approximately half nontumorous chronic liver disease tissues.