Microglia: first responders in the central nervous system.

摘要: Microglia has emerged not only as an essential inflammatory cell but also a major player in the development of adult brain. phagocytize extra-numerical synapses during postnatal development, maintain and strengthen remaining subset synapses, remodel synaptic circuits clearing apoptotic newborn neurons. Thereby, microglia plays crucial role for establishment, plasticity function neural circuits. In addition to key normal brain function, any imbalance activity been associated with neurodegenerative diseases. Microglial cells respond rapidly smallest pathological changes, this being vital aspect many tissue scaring local confinement focal lesions. It is assumed that high motility microglial represents important requirement fulfill numerous functions. review will highlight healthy injured brain, discuss how impairment can affect function.