Multi-scale and reduced modelling of biological systems
作者： Ruxandra Barbulescu , Daniel Ioan
DOI: 10.1109/ATEE.2015.7133876
关键词:
摘要: In systems biology there is an intrinsic need for multiscale modelling, because physiological functions account many spatial / time scales and processes, with a close connection between multi-scale, multi-physics approaches model reduction. The paper overview attempting to transmit new perspective on modelling of complex biological systems. We discuss the key points in system-level analysis multi-scale bio-systems, making classification methods used different characterizing approach. main contribution presentation role importance complexity reduction biosystems, proposing this respect procedure proven be efficient multiphysics structures.
sci-hub.se 参考文章(35)
Thomas Hou, Yalchin Efendiev, Multiscale Finite Element Methods: Theory and Applications ,(2009)
K. Bettenbrock, A. Kremling, J. Stelling, Martin Ginkel, E. D. Gilles, Towards a Virtual Biological Laboratory MIT Press. pp. 189- 212 ,(2001)
Ramon Grima, Multiscale Modeling of Biological Pattern Formation Current Topics in Developmental Biology. ,vol. 81, pp. 435- 460 ,(2008) , 10.1016/S0070-2153(07)81015-5
Dmitry Missiuro Vasilyev, Jacob K. White, Theoretical and practical aspects of linear and nonlinear model order reduction techniques Massachusetts Institute of Technology. ,(2008)
N. Spennagallo, L. Codecasa, P. Maffezzoni, D. D'Amore, A novel approach for generating dynamic compact models of thermal networks having large numbers of power sources THERMINIC 2005. ,vol. 1, pp. 25- 31 ,(2005)
Zhaojun Bai, Patrick M. Dewilde, Roland W. Freund, Reduced-Order Modeling Handbook of Numerical Analysis. ,vol. 13, pp. 825- 895 ,(2005) , 10.1016/S1570-8659(04)13009-3
Athanasios C. Antoulas, Approximation of Large-Scale Dynamical Systems ,(2005)
Z. N. Oltvai, SYSTEMS BIOLOGY: Life's Complexity Pyramid Science. ,vol. 298, pp. 763- 764 ,(2002) , 10.1126/SCIENCE.1078563
Victorita Dolean, Pierre Jolivet, Frédéric Nataf, Nicole Spillane, Hua Xiang, Two-Level Domain Decomposition Methods for Highly Heterogeneous Darcy Equations. Connections with Multiscale Methods Oil & Gas Science and Technology – Revue d’IFP Energies nouvelles. ,vol. 69, pp. 731- 752 ,(2014) , 10.2516/OGST/2013206
Huan-Xiang Zhou, Theoretical frameworks for multiscale modeling and simulation. Current Opinion in Structural Biology. ,vol. 25, pp. 67- 76 ,(2014) , 10.1016/J.SBI.2014.01.004