Lipid mediators in ocular inflammatory models

摘要: textabstractUveitis, an acute or chronic inflammation of the uveal tissue eye, and keratitis, corneal tissue, may have their cause in bacterial, protozoal viral infection. No etiological agent can be found some patients. In these cases therapy has to symptomatic nature. One the major causes destruction ocular tissues uveitis and keratitis is production lysosomal enzymes by infiltrating white blood cells. Inhibition either cellular infiltration of tissue prevention enzyme release these cells will lead less tissue. In this study we investigated cellular infiltration tissue topical systemic administration agents interfering with lipid mediators. An Arthus reaction (delayed hypersensitivity reaction) of the cornea uvea rabbit eye initiated by injection antigen respectively corneal stroma or vitreous body. The clinical symptoms subsequent antigenantibody reaction are conjunctival hyperemia, an annular leukocytes (ring Wessely), stromal edema, neovascularization cornea.l Symptoms elicited intravitreal injection blood-aqueous barrier breakdown (visible a slitlamp as flare) presence of infiltrated anterior chamber vitreous 2 ' 3 Phospholipid derivatives act mediators human and animal inflammatory disease. These cell membrane phospholipids platelet-activating factor (PAF) arachidonic acid. Arachidonic acid further metabolized to prostaglandins (PGs) leukotrienes (LTs).