作者: Z. A. YEGIN , H. PAŞAOĞLU , Ş. Z. AKI , Z. N. ÖZKURT , C. DEMIRTAŞ
DOI: 10.1111/J.1751-553X.2011.01297.X
关键词:
摘要: Summary Introduction: Pretransplantation iron overload (IO) is considered as a predictor of adverse outcome in hematopoietic stem cell transplantation (HSCT). Peroxidative tissue injury caused by IO leads to progressive organ dysfunction. Methods: This retro-prospective study which explores the possible relationship between IO, oxidative stress and transplant outcome. Serum samples 149 consecutive HSCT candidates were subjected analysis parameters, including nontransferrin bound (NTBI) pro-oxidant/antioxidant status. Results: ferritin was found be positively correlated with NTBI negatively glutathione peroxidase (GPx) superoxide dismutase (SOD). An inverse correlation SOD, total antioxidant potential (TAP) malonyldialdehide (MDA) also demonstrated. impact serum level on early posttransplant complications pulmonary toxicity, fungal infections sinusoidal obstruction syndrome (SOS) shown. A significant +30 day (P = 0.027) +100 day survival (P = 0.028) shown auto-transplanted patients. MDA levels had autologous (P = 0.047; P = 0.026) allogeneic (P = 0.053; P = 0.059) groups. GPx (P = 0.016) (P = 0.021) identified independent prognostic parameters for overall allo-transplanted patients. Conclusion: might major contributor recipients through an impaired pro-oxidative/antioxidative homeostasis. The reversible nature suggests that preventive strategies have improve