Pro-oxidative/antioxidative imbalance: a key indicator of adverse outcome in hematopoietic stem cell transplantation

作者: Z. A. YEGIN , H. PAŞAOĞLU , Ş. Z. AKI , Z. N. ÖZKURT , C. DEMIRTAŞ

DOI: 10.1111/J.1751-553X.2011.01297.X

关键词:

摘要: Summary Introduction:  Pretransplantation iron overload (IO) is considered as a predictor of adverse outcome in hematopoietic stem cell transplantation (HSCT). Peroxidative tissue injury caused by IO leads to progressive organ dysfunction. Methods:  This retro-prospective study which explores the possible relationship between IO, oxidative stress and transplant outcome. Serum samples 149 consecutive HSCT candidates were subjected analysis parameters, including nontransferrin bound (NTBI) pro-oxidant/antioxidant status. Results:  ferritin was found be positively correlated with NTBI negatively glutathione peroxidase (GPx) superoxide dismutase (SOD). An inverse correlation SOD, total antioxidant potential (TAP) malonyldialdehide (MDA) also demonstrated. impact serum level on early posttransplant complications pulmonary toxicity, fungal infections sinusoidal obstruction syndrome (SOS) shown. A significant +30 day (P = 0.027) +100 day survival (P = 0.028) shown auto-transplanted patients. MDA levels had autologous (P = 0.047; P = 0.026) allogeneic (P = 0.053; P = 0.059) groups. GPx (P = 0.016) (P = 0.021) identified independent prognostic parameters for overall allo-transplanted patients. Conclusion:  might major contributor recipients through an impaired pro-oxidative/antioxidative homeostasis. The reversible nature suggests that preventive strategies have improve

参考文章(43)
MA Livrea, L Tesoriere, AM Pintaudi, A Calabrese, A Maggio, HJ Freisleben, D D'Arpa, R D'Anna, A Bongiorno, Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood. ,vol. 88, pp. 3608- 3614 ,(1996) , 10.1182/BLOOD.V88.9.3608.BLOODJOURNAL8893608
M. Morado, E. Ojeda, J. Garcia-Bustos, M. J. Aguado, R. Arrieta, E. Quevedo, A. Navas, F. Hernandez-Navarro, Serum Ferritin as Risk Factor for Veno-occlusive Disease of the Liver. Prospective Cohort Study. Hematology. ,vol. 4, pp. 505- 512 ,(1999) , 10.1080/10245332.1999.11746478
Philippe Armand, Haesook T. Kim, Corey S. Cutler, Vincent T. Ho, John Koreth, Edwin P. Alyea, Robert J. Soiffer, Joseph H. Antin, Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation Blood. ,vol. 109, pp. 4586- 4588 ,(2007) , 10.1182/BLOOD-2006-10-054924
Przepiorka D, Weisdorf D, Hows J, Beatty P, Martin P, Klingemann Hg, Thomas Ed, 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplantation. ,vol. 15, pp. 825- 828 ,(1995)
Tamotsu Yoshioka, Kiyoya Kawada, Toshie Shimada, Mariko Mori, Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood American Journal of Obstetrics and Gynecology. ,vol. 135, pp. 372- 376 ,(1979) , 10.1016/0002-9378(79)90708-7
G. Lucarelli, R.A. Clift, M. Galimberti, E. Angelucci, C. Giardini, D. Baronciani, P. Polchi, M. Andreani, D. Gaziev, B. Erer, A. Ciaroni, F. D’Adamo, F. Albertini, P. Muretto, Bone Marrow Transplantation in Adult Thalassemic Patients Blood. ,vol. 93, pp. 1164- 1167 ,(1999) , 10.1182/BLOOD.V93.4.1164
J Maertens, H Demuynck, EK Verbeken, P Zachée, GEG Verhoef, P Vandenberghe, MA Boogaerts, Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplantation. ,vol. 24, pp. 307- 312 ,(1999) , 10.1038/SJ.BMT.1701885
Itsaraet Gosriwatana, Olivier Loreal, Shuli Lu, Pierre Brissot, John Porter, Robert C. Hider, Quantification of Non-Transferrin-Bound Iron in the Presence of Unsaturated Transferrin Analytical Biochemistry. ,vol. 273, pp. 212- 220 ,(1999) , 10.1006/ABIO.1999.4216