Determinants of rupture of atherosclerotic coronary lesions

摘要: Coronary atherosclerosis without thrombosis is generally a benign disease that asymptomatic or presents as chronic stable angina. The great majority of patients can be treated pharmacologically, and in those with intractable angina percutaneous surgical revascularization are available high initial success good long-term prognosis. acute manifestations coronary — unstable angina, myocardial infarction, sudden cardiac death share common pathophysiologic phenomena: thrombosis. This life threatening complication usually occurs at the site plaque fissure rupture. Several studies have shown rupture plays key role pathophysiology syndromes [1]. Recent observations indicate it not severity stenosis (plaque volume) determines outcome; type composition) extent collateral development [2].