Spread and evolution of Plasmodium falciparum drug resistance
作者： Toshihiro Mita , Kazuyuki Tanabe , Kiyoshi Kita
DOI: 10.1016/J.PARINT.2009.04.004
关键词:
摘要: Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials, chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health problem in many endemic regions. Recent discovery resistance-associated genes, pfcrt, pfmdr1, dhfr, dhps, applications microsatellite markers flanking the genes have revealed evolution parasite these antimalarials geographical resistance. Here, we review our recent knowledge sulfadoxine/pyrimethamine. In both appears be largely explained by invasion limited resistant lineages However, multiple, indigenous evolutionary origins also demonstrated. Further molecular population genetic approaches will greatly facilitate understanding resistance, contribute developing strategies for better control malaria.
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