Sex differences in atheroma burden and endothelial function in patients with early coronary atherosclerosis.
作者： S. H. Han , J. H. Bae , D. R. Holmes , R. J. Lennon , E. Eeckhout
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摘要: Aims Women and men have different clinical presentations outcomes in coronary artery disease (CAD). We tested the hypothesis that sex differences may influence atherosclerotic burden endothelial function before development of obstructive CAD. Methods results A total 142 patients (53 men, 89 women; mean ± SD age, 49.3 11.7 years) with early CAD simultaneously underwent intravascular ultrasonography assessment. Atheroma left main proximal anterior descending (LAD) arteries was significantly greater than women (median, 23.0% vs. 14.1%, P = 0.002; median, 40.1% 29.3%, 0.001, respectively). eccentricity LAD higher 0.89 0.80, 0.04). The length segments dysfunction longer 39.2 11.1 mm, 0.002). In contrast, maximal flow reserve lower (2.80 3.30, < 0.001). Sex an independent predictor atheroma (both 0.05) by multivariate analysis. Conclusion Men burden, more eccentric atheroma, diffuse epicardial women. These suggest severe structural functional abnormalities women, even atherosclerosis, which result incidence rates ST-segment myocardial infarction
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